CASP 1 ( caspase 1 , apoptosis - related cysteine peptidase ( interleukin 1 , beta , convertase ) )
نویسنده
چکیده
منابع مشابه
CASP 8 ( Caspase 8 , Apoptosis - Related Cysteine Peptidase )
Review on CASP8, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
متن کاملCASP - 9 ( caspase 9 , apoptosis - related cysteine peptidase )
Three mRNA isoforms have been identified in Homo sapiens. Caspase-9S, also classified as caspase-9b or caspase9beta, is a small variant of caspase-9 lacking exons 3-6, which contain the catalytic domain. Caspase-9S functions as an endogenous dominant-negative isoform of full-length caspase-9 by binding to the Apaf-1 protein thus hampering its binding and processing of the full-length procaspase...
متن کاملSalmonella Exploits Caspase-1 to Colonize Peyer's Patches in a Murine Typhoid Model
Salmonella typhimurium invades host macrophages and induces apoptosis and the release of mature proinflammatory cytokines. SipB, a protein translocated by Salmonella into the cytoplasm of macrophages, is required for activation of Caspase-1 (Casp-1, an interleukin [IL]-1beta-converting enzyme), which is a member of a family of cysteine proteases that induce apoptosis in mammalian cells. Casp-1 ...
متن کاملThe caspase family of cysteine proteases.
The discovery that CED-3, the product of a gene necessary for programmed cell death in the nematode Caenorhabditis elegans, is related to the mammalian cysteine protease interleukin-1 beta converting enzyme (ICE/caspase-1) has led to intense interest in the role of proteases in apoptosis. It is now clear that at least some members of the caspase (ICE/CED-3) family, which at present includes ten...
متن کاملMutational analysis of the Caenorhabditis elegans cell-death gene ced-3.
Mutations in the gene ced-3, which encodes a protease similar to interleukin-1beta converting enzyme and related proteins termed caspases, prevent programmed cell death in the nematode Caenorhabditis elegans. We used site-directed mutagenesis to demonstrate that both the presumptive active-site cysteine of the CED-3 protease and the aspartate residues at sites of processing of the CED-3 proprot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011